Yes. One option is to use the VS Bootstrapper. The Bootstrapper will bundle all of your apps necessary pre-requisite’s, install them when run & then start the “ClickOnce” application install. The Bootstrapper must be run the 1st time each user uses the app. The “ClickOnce” application will still be auto-updatable & launch able via the network. However, the pre-requisites themselves will not be auto-updateable via “ClickOnce”.