Most applications won’t have to know anything about “ClickOnce” to be deployed with “ClickOnce”. In most cases, using “ClickOnce” is as simple as creating the necessary manifest files & placing the application on a server… for which we provide tools. The main consideration to keep in mind is what dependencies your application has (ex. installing drivers, redists, shared components). The more dependencies your application has, the more difficult it will be to use “ClickOnce”.

In your VS projects, use project-to-project references if you have factored your application into components. Use content files to manage loose external files required by your client application, such as help content, bitmaps, local databases, etc.